This talk will introduce optical elements displayed with liquid-crystal spatial light modulators (SLMs). These pixelated microdisplays are useful for encoding optical phase functions and controlling the polarization of light. Modern SLMs exhibit high spatial resolution and precise control of optical retardance, allowing them to display diffractive elements. They have become key components for...
Optical fibers can act as continuous sensors, turning guided light into a tool to measure temperature, strain, and vibration along their entire length. Originally developed for large-scale monitoring of structures and the environment, distributed fiber sensing has recently advanced to millimeter-scale spatial resolution, opening the door to high-resolution, minimally invasive measurements in...
Astrocytes are cells in the central nervous system involved in numerous functions, from the regulation of neurotransmission to the maintenance of ionic and metabolic homeostasis, as well as memory and learning[1]. However, how astrocytes contribute to these diverse processes is still only partially understood. Here, I will illustrate how computational approaches are providing novel insights...
Neurological diseases such as neurodegeneration, stroke, and brain tumors are often studied as separate conditions, yet they share common neuroimaging features and biological mechanisms. This talk introduces the human brain connectome as a unifying framework to explain how molecular pathology, focal lesions, and structural damage spread across large-scale brain networks. Alterations in brain...
The brain undergoes radical changes during the first years of life, which lay the foundations for many essential perceptual and cognitive abilities, such as language use or face perception. Imaging these neural changes is thus highly relevant, but not easy, as infants are challenging research participants. Near-infrared spectroscopy (NIRS) is a relatively new brain imaging technique, which is...
The coordination of cellular activities relies on the close positioning of intracellular organelles at membrane contact sites (MCSs), which has been found altered in several diseases. However, MCS study has been hampered by the lack of tools allowing to track membrane proximity with high spatial and temporal resolution. To address this limitation, we developed reversible fluorescent probes...
The development and function of neuronal circuits depend on the precise organization of neuronal morphology and synaptic architecture. These processes are shaped by intercellular communication mechanisms, including astrocyte-derived signals influencing neuronal growth, branching and synapse formation[1]. Although advanced microscopy provides detailed structural information, extracting robust...
Neural circuits underpin behavior, yet dissecting their function at single-cell resolution remains challenging due to complexity and inaccessibility in vivo. In this talk, I will show how larval zebrafish (Danio rerio) enables optical approaches that connect brain-wide activity to circuit organization and behavior. Leveraging volumetric calcium imaging, I will present experiments probing...
