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5/19/26, 3:00 PMCells, microbes, and extracellular vesicles manipulationOral
Blood cell - vessel wall interactions are critical both for the flow of red blood cells, and for the control of white blood cell adhesion to the walls (e.g. at a site of inflammation). However, the biochemical and mechanical cues governing their tight regulation are still poorly understood, in particular because of the challenge of non-invasive investigation of cell-wall short-range...
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5/19/26, 3:20 PMCells, microbes, and extracellular vesicles manipulationOral
The mechanical properties of lipid membranes play an important role in diverse processes, ranging from cellular processes like endocytosis and cytokinesis to cell-cell interactions as well as for diseases like cancer or blood disorders and vesicle based drug delivery systems. Established techniques to probe these mechanics, like micropipette aspiration or optical tweezers however, typically...
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5/19/26, 3:40 PMCells, microbes, and extracellular vesicles manipulationOral
We develop a mother machine-like microfluidic device specifically designed to track the proliferation of single T-cells via live-cell microscopy.
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Although numerous microfluidic setups have been developed to study cell proliferation at the single-cell level, most of them are optimized for bacteria, which do not require particularly demanding growth conditions, or for use on adherent cells,... -
5/19/26, 4:00 PMCells, microbes, and extracellular vesicles manipulationOral
Background and aims: The selection of cellulolytic microorganisms, together with the ability to bridge the genotype-to-phenotype gap, is essential for biotechnological applications such as biofuel production, lignocellulosic waste valorisation, and soil bioremediation. Conventional screening methods based on cultivation on selective solid media are typically time-consuming, low-throughput, and...
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5/19/26, 6:00 PMFlow, wetting, and transport phenomenaOral
Cell viability is a fundamental parameter in biomedical research, as it reflects the functional state of a cell population by integrating key aspects of cellular health, including membrane integrity, metabolic activity, and proliferative capacity [Khalef et al.(2024)]. It plays a critical role in diagnostics and pharmacological studies, supporting the investigation of pathological processes,...
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Catherine Xu (ETH Zürich)5/19/26, 6:20 PMCells, microbes, and extracellular vesicles manipulationOral
Single-cell technologies have become a crucial tool for investigating biological systems by enabling detailed characterisation of cellular heterogeneity. Beyond measurements of individual modalities such as the transcriptome or proteome, multi-omic approaches capturing multiple molecular identities from the same cell, have provided further insights into dissecting complex biological...
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