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5/18/26, 2:00 PMOrgan-on-a-chip and translational modelsOral
In vitro models of the airway epithelium are essential for studying respiratory physiology yet commonly used systems rely on static culture conditions that lack mechanical stimulation at the tissue surface. In particular, conventional air–liquid interface (ALI) Transwell models maintain epithelial tissues without fluid flow on either the apical or basal side, leading to limited control over...
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5/18/26, 2:20 PMOrgan-on-a-chip and translational modelsOral
Pulmonary bronchi are lined with a thin layer of mucus, which protects the airways from foreign particulate, such as dust and pathogens. In order to remove this mucus from the lung, the epithelium of the lung is covered in ciliated cells, which beat, moving the mucus up and out of the bronchi to the throat. Dysfunction in this mucociliary clearance can originate from both the cilia, such as...
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Iyad Abou Shakra (laboratoire charles coulomb (L2C))5/18/26, 2:40 PMOrgan-on-a-chip and translational modelsOral
The human bronchial epithelium is a dynamic barrier that forms the first line of defense against inhaled threats such as pollutants and respiratory pathogens. Its protective role mainly depends on two key cell types: i) goblet cells that secrete mucus, a viscoelastic fluid that traps foreign particles entering the human body and ii) ciliated cells, which have hair-like structures that beat in...
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5/18/26, 3:00 PMOrgan-on-a-chip and translational modelsOral
Despite extensive preclinical efforts, effective therapies for brain disorders remain scarce, largely due to the limited predictive power of existing experimental models. While many candidate compounds show robust efficacy in animal models, translation to human patients has been disappointing. This gap underscores the need for scalable, human-relevant platforms capable of recapitulating key...
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Jessica Vandensteen (Institut Curie, Université PSL, Sorbonne Université (Paris, France) - CNRS UMR 168, Physics of Cells and Cancer)5/18/26, 4:40 PMOrgan-on-a-chip and translational modelsOral
The Autosomal Dominant Polycystic Kidney Disease (ADPKD), is the most common genetic kidney disease, leading to the development of numerous cysts in the renal tubules, and ultimately to kidney failure, without any curative treatment to date. Despite numerous genetic and cell biology studies of ADPKD, the precise mechanism of its cystogenesis, resulting from localized dilation of the renal...
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Chloé Humbert5/18/26, 5:00 PMOrgan-on-a-chip and translational modelsOral
Objective : Development of an organ-on-a-chip dedicated to the study of chemical toxicity via the skin. The main technological objective presented here is based on the integration of biocompatible and photo-polymerizable hydrogel separators that can mimic the dermis, accommodate suitable co-cultures, and support the epidermis.
The organ-on-a-chip (OoC) technology can reproduce selected...
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Jules Edwards (LAAS-CNRS)5/18/26, 5:20 PMOrgan-on-a-chip and translational modelsOral
The lymphatic system is a network of unidirectional vessels that plays an essential role in the control of tissue homeostasis, immune surveillance, and is also involved in metastatic processes [1]. Its function is dynamically regulated by molecular signals — such as vascular endothelial growth factors (VEGFs) — and physical cues. While VEGFs and their associated receptors are known to promote...
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